Variations in brain genome and psychiatric disorders

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  • Bundo Miki
    Department of Molecular Psychiatry, Graduate School of Medicine, the University of Tokyo
  • Kasai Kiyoto
    Department of Neuropsychiatry, Graduate School of Medicine, the University of Tokyo
  • Kato Tadafumi
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute
  • Iwamoto Kazuya
    Department of Molecular Psychiatry, Graduate School of Medicine, the University of Tokyo

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  • 脳ゲノム多様性と精神疾患
  • ノウ ゲノム タヨウセイ ト セイシン シッカン

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Abstract

Complex interaction of genetic and environmental factors is believed to cause psychiatric disorders. Despite the extensive efforts, the genetic factors of psychiatric disorders are still not known. Recently, it has been reported that genomic DNA derived from brain tissue contain quantitative and qualitative differences. For example, epigenetic modification of cytosine residue is considered as a qualitative difference, and copy number variations, chromosomal aneuploidy, and dynamics of retrotransposon are considered as the quantitative differences. We discuss about the recent studies about these variations in brain genome and their possible association with psychiatric disorders.

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