画像処理を利用する微小血管内血栓形成過程の定量的解析法

DOI
  • 鄭 筱祥
    中国浙江大学光電与科学儀器系生物医学工程研究所
  • 寧 鋼民
    中国浙江大学光電与科学儀器系生物医学工程研究所
  • 林 文
    中国浙江大学光電与科学儀器系生物医学工程研究所
  • 大島 宣雄
    筑波大学基礎医学系医工学

書誌事項

タイトル別名
  • Development of image processing method for quantitative analysis of thrombus formation process in the microcirculation

抄録

Using a intravascular thrombus formation model produced by irradiation of the filtered light and intravascualr administration of fluorescein sodium, we developed an image processing technique to study the dynamic process of thrombus formation in vivo. Recorded video images were converted into the digital images and analyzed by an IBM PC/386 personal computer. To improve the quality of digitized images we utilized the digital filtering and smoothing method. We then used segmental analysis method and differential histogram to distinguish the regions of the blood flow and the thrombus. The image processing technique thus developed enabled measurement of time course changes of thrombus size. In animal experiments we found the thrombus growth and separation were balanced during the procedure of thrombus formation. This method is useful for studying mechanism of thrombus growth and evaluating the pharmacological effects of anti-platelet aggregating drugs.

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390001205421089536
  • NII論文ID
    130001933540
  • DOI
    10.11262/jpnbr1987.7.2_26
  • ISSN
    09134778
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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