マウス仁形成体部位の銀染色性の補償的変化〔英文〕

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  • SUZUKI Hitoshi
    Division of Molecular Genetics, Institute of Medical Science, Jikei University School of Medicine
  • SAKURAI Susumu
    Division of Molecular Genetics, Institute of Medical Science, Jikei University School of Medicine
  • NISNIMURA Masahiko
    Institute of Experimental Animals, Hamamatsu University School of Medicine
  • KOMINAMI Ryo
    Department of Biochemistry, Faculty of Medicine, Niigata University
  • MORIWAKI Kazuo
    Department of Cell Genetics, National Institute of Genetics

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タイトル別名
  • Compensatory changes in silver-stainability of nucleolar organizer regions in mice.
  • マウス ジン ケイセイタイ ブイ ノ ギン センショクセイ ノ ホショウテキ

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Silver-stainability of nucleolar organizer regions (NORs) that contain genes for ribosomal RNA (rDNA) was investigated using two mouse strains, BALB/cCrSlc and MOA, and their hybrid progeny. The patterns of segregation of the rDNA clusters were analyzed in terms of chromosomal C-banding and by use of a polymorphic probe for the variable region in backcrossed N2 and N3 individuals. The results indicate that the intensity of Ag-NOR staining is stably inherited in most of the rDNA clusters, irrespective of different genetic backgrounds. In some clusters, such as those on chromosome 12 of BALB/cCrSlc, a modulation of the intensity is observed. This modulation seems to be due to compensatory activation via a change in the number of actively transcribed genes. The change from silver-negative to silver-positive staining of the NOR of chromosome 12 of BALB/cCrSlc was correlated with demethylation of the genes.<br>

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