周生期低酸素症におけるラット新生仔脳の電顕的研究

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  • Electron Microscopic Study of Newborn Rat Brain after Experimental Fetal Anoxia
  • シュウセイキ テイ サンソショウ ニ オケル ラット シンセイシ ノウ ノ デ

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In order to investigate a mechanism of perinatal anoxic brain damage the cerebral cortex of newborn rat with anoxic episodes in intrauterine life was examined mainly by using electron microscope.<BR>After anaesthesia induced by intramuscular injection of sodium nembutal, pregnant rats of 18th gestational day were operated on the abdominal wall to expose a small portion of the uterus. Unilateral uterine arteries were clamped by forcets for 2 minutes, and then 1 minute-relaps in clump-free condition was followed. The same procedure was repeated 5 times by means of Nakamura's method.<BR>After the uterus was restored into the abdominal cavity, the abdominal walls were sutured up. Thereafter, the gastation was resumed for the successive 3 days.<BR>Newborn rat brain was cut out and immediately fixed in 2 %glutaraldehyde after birth. The central gyri of the brain tissue was examined by electron microscopy on one day,7 days,2 weeks,3 weeks,4 weeks,5 weeks,6 weeks,7 weeks and 8 weeks after birth, respectively and the following results were obtained.

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