重症クモ膜下出血後のsymptomatic vasospasm に対する ticlopidine, albumin, nicardipineの併用療法(TAN-therapy) の有効性について

DOI

書誌事項

タイトル別名
  • Prevention of the Symptomatic vasospasm in Poor Risk Aneurysmal Patients by Ticlopidine, Albumin and Nicardipine (TAN-Therapy)
  • -血液凝固系および中大脳動脈血流速度からの検討-

抄録

The pathogenesis of symptomatic vasospasm following subarachnoid hemorrhage is still unclear. To clarify this, we analyzed changes of blood coagulation activities between 65 poor risk aneurysmal patients treated by a combination with ticlopidine, albumin and nicardipine (so called TAN therapy) and in 52 untreated patients with symptomatic vasospasm. The hypercoagulable state was scored according to the Disseminated Intravascular Coagulation (DIC) scoring system. Our clinical studies showed that severe SAH following aneurysmal rupture caused the hypercoagulable state. There were good correlations between the degree of hypercoagulation and the severity of the symptomatic vasospasm. TAN therapy reduced the DIC scores by antiplatelet agent and prevented the occurrence of the symptomatic vasospasm in severe SAH. These facts support the beneficial effects of TAN therapy in prevention of symptomatic vasospasm in severe SAH.

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詳細情報 詳細情報について

  • CRID
    1390001205464291328
  • NII論文ID
    130004668275
  • DOI
    10.2335/scs1987.19.2_247
  • ISSN
    09145508
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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