膵液の胆道内逆流と発癌との関係

DOI

書誌事項

タイトル別名
  • A study on the association between pancreatic juice reflux into the biliary tract and cholangiocarcinogenesis
  • a study in rat models of bile duct dilatation
  • 胆管拡張モデルにおける検討

抄録

To study the association between pancreatic juice reflux into the biliary tract and cholangiocarcinogenesis, we used dibutyltin dichloride (DBTC) -treated rats as our model of bile duct dilatation. Moreover, we compared the DBTC-treated model with rats with bile ducts ligated near the duodenum or at the porta hepatica. The epithelium of the extra hepatic bile duct in the DBTC-treated rats and the rats with ligation near the duodenum exhibited cell proliferation and COX-2expression. Since these changes may be caused by the reflux of pancreatic juice into the biliary tract, the models seemed to closely resemble pancreaticobiliary maljunction in man. Furthermore, the increase in COX-2 expression in both models suggests that there is an association between the pancreatic juice reflux and cholangiocarcinogenesis.

収録刊行物

  • Tando

    Tando 19 (1), 16-22, 2005

    Japan Biliary Association

キーワード

詳細情報 詳細情報について

  • CRID
    1390001205465079040
  • NII論文ID
    130004675751
  • DOI
    10.11210/tando1987.19.1_16
  • ISSN
    09140077
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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