コレステロール胆石形成モデルにおける大柴胡湯 (TJ-8) による胆石形成抑制効果
書誌事項
- タイトル別名
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- Inhibitory effects of Dai-saiko-to (TJ-8) on the cholesterol gallstone formation in hamsters
- グルコース食投与ハムスターを用いて
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説明
The effect of Dai-saiko-to (TJ-8) on the cholesterol gallstone formation was investigated in hamsters fed a high glucose diet, as an experimental model for cholesterol gallstone formation. Animals were fed a normal chow or 75% (w/w) glucose diet (lithogenic diet) with or without 1% Dai-saiko-to (w/w) for 4 weeks. The gallstone incidence was 71% in animals fed a high glucose diet, whereas no stones were formed in the other groups. Thus, cholesterol gallstone formation was prevented by the treatment with Dai-saiko-to. The increase in tissue cholesterol (serum, liver, bile)by high glucose feeding was significantly suppressed by Dai-saiko-to. Further, the appearance rate of cholesterol monohydrate crystal in bile or on the surface of gallbladder was significantly reduced in animals treated with Dai-saiko-to. These findings suggest that Dai-saiko-to prevents cholesterol gallstone formation by reducing the bile cholesterol saturation index, and that the reduction in intestinal cholesterol absorption and hepatic cholesterol synthesis may attribute to such an action of Dai-saiko-to.
収録刊行物
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- Tando
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Tando 8 (1), 9-13, 1994
Japan Biliary Association
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詳細情報 詳細情報について
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- CRID
- 1390001205467640960
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- NII論文ID
- 130004675984
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- ISSN
- 09140077
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可