R50547(Levocabastine hydrochloride)点鼻剤の通年性アレルギー性鼻炎に対する臨床的効果
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- 奥田 稔
- Japan Asthma and Allergy Clinic
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- 鳥山 稔
- Department of Otorhinolaryngology, International National Medical Center of Japan
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- 宇佐神 篤
- Department of Otorhinolaryngology, Hamamatsu Medical Center
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- 関谷 透
- Department of Otorhinolaryngology, Shimonoseki National Hospital
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- 茂木 五郎
- Department of Otorhinolaryngology, Medical College of Oita
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- 吉村 理
- Department of Otorhinolaryngology, Sapporo City Hospital
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- 八木 聰明
- Department of Otorhinolaryngology, Nippon Medical School
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- 大久保 公裕
- Department of Otorhinolaryngology, Nippon Medical School
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- 大西 正樹
- Department of Otorhinolaryngology, Nippon Medical School
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- 横島 一彦
- Department of Otorhinolaryngology, Nippon Medical School
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- 大塚 博邦
- Department of Otorhinolaryngology, Dai)ni Hospital, Nippon Medical School
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- 目澤 朗憲
- Department of Otorhinolaryngology, Hakujikai Memorial General Hospital
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- 池田 雅一
- Department of Otorhinolaryngology, Shitaya Hospital
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- 森園 徹志
- Department of Otorhinolaryngology, Yatsu Insurance Hospital
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- 増田 哲也
- Department of Otorhinolaryngology, International National Medical Center of Japan
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- 清水 啓成
- Department of Otorhinolaryngology, International National Medical Center of Japan
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- 舩坂 宗太郎
- Department of Otorhinolaryngology, Tokyo Medical College
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- 斎藤 啓光
- Department of Otorhinolaryngology, Tokyo Medical College
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- 鄭 正舟
- Department of Otorhinolaryngology, Tokyo Medical College
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- 新井 雅之
- Department of Otorhinolaryngology, Hachioji Medical Center, Tokyo Medical College
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- 河合 真
- Department of Otorhinolaryngology, Kasumigaura Hospital, Tokyo Medical College
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- 佐伯 哲郎
- Department of Otorhinolaryngology, Kosei Central Hospital
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- 小泉 理華子
- Department of Otorhinolaryngology, Kosei Central Hospital
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- 植田 宏
- Department of Otorhinolaryngology, Kamata General Hospital
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- 渡嘉敷 亮二
- Department of Otorhinolaryngology, Meitokukai General Shinkawahashi Hospital
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- 永瀬 茂代
- Department of Otorhinolaryngology, Tokokai Toda Central General Hospital
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- 大塚 幸之
- Department of Otorhinolaryngology, Warabi City Hospital
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- 調所 廣之
- Department of Otorhinolaryngology, Kanto Rosai Hospital
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- 石井 豊太
- Department of Otorhinolaryngology, Sagamihara National Hospital
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- 矢島 洋
- Department of Otorhinolaryngology, Shizuoka Saiseikai General Hospital
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- 瀧本 勲
- Department of Otorhinolaryngology, Aichi Medical University, School of Medicine
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- 堀 瑞代
- Department of Otorhinolaryngology, Aichi Medical University, School of Medicine
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- 岩崎 博
- Department of Otorhinolaryngology, Toki City Hospital
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- 郡山 智也
- Department of Otorhinolaryngology, Toki City Hospital
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- 山田 一美
- Department of Otorhinolaryngology, Nagoya Ekisaikai Hospital
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- 辻本 茂
- Department of Otorhinolaryngology, Asahi Rosai Hospital
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- 小林 加代子
- Department of Otorhinolaryngology, Gifu Koseiren Showa Hospital
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- 丹羽 英人
- Department of Otorhinolaryngology, Nagoya National Hospital
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- 佐藤 正博
- Department of Otorhinolaryngology, Nagoya National Hospital
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- 高橋 宏明
- Department of Otorhinolaryngology, Osaka Medical College
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- 井上 功
- Department of Otorhinolaryngology, Osaka Medical College
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- 川上 理郎
- Department of Otorhinolaryngology, Saiseikai Nakatsu Hospital
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- 和田 公平
- Department of Otorhinolaryngology, Hirakata City Hospital
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- 雲井 健雄
- Department of Otorhinolaryngology, Hyogo College of Medicine
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- 里見 文男
- Department of Otorhinolaryngology, Hyogo College of Medicine
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- 藤木 宏也
- Department of Otorhinolaryngology, Takarazuka City Hospital
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- 伊達 和宏
- Department of Otorhinolaryngology, Hyogo Prefectural Awaji Hospital
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- 吉村 史郎
- Department of Otorhinolaryngology, Ashiya City Hospital
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- 榎本 雅夫
- Department of Otorhinolaryngology, Wakayama Red Cross Hospital
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- 硲田 猛真
- Department of Otorhinolaryngology, Wakayama Red Cross Hospital
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- 柳原 尚明
- Department of Otorhinolaryngology, Ehime University, School of Medicine
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- 菊池 孝
- Department of Otorhinolaryngology, Ehime University, School of Medicine
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- 有友 宏
- Department of Otorhinolaryngology, Matsuyama Red Cross Hospital
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- 中村 光士郎
- Department of Otorhinolaryngology, Ehime Prefectural Central Hospital
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- 増田 游
- Department of Otorhinolaryngology, Okayama University, School of Medicine
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- 大道 卓也
- Department of Otorhinolaryngology, Okayama University, School of Medicine
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- 竹久 亨
- Department of Otorhinolaryngology, Tsuyama Central Hospital
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- 中田 道広
- Department of Otorhinolaryngology, Tsuyama Central Hospital
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- 斉藤 稚里
- Department of Otorhinolaryngology, Okayama City Hospital
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- 折田 洋造
- Department of Otorhinolaryngology, Kawasaki Medical College
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- 林 琢巳
- Department of Otorhinolaryngology, Sato Memorial Hospital
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- 西岡 慶子
- Department of Otorhinolaryngology, Hiroshima City Hospital
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- 高橋 正紘
- Department of Otorhinolaryngology, Yamaguchi University, School of Medicine
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- 今手 祐二
- Department of Otorhinolaryngology, Yamaguchi University, School of Medicine
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- 日吉 正明
- Department of Otorhinolaryngology, Yamaguchi Prefectural Central Hospital
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- 守谷 啓司
- Department of Otorhinolaryngology, Nagato General Hospital
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- 奥園 達也
- Department of Otorhinolaryngology, Shimonoseki National Hospital
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- 小川 暢也
- Department of Pharmacology, Ehime University School of Medicine
書誌事項
- タイトル別名
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- Clinical investigation of R 50547 (Levocabastine hydrochloride) nasal spray in perennial allergic rhinitis
- phase III comparative trial with Sodium Cromoglicate
- クロモグリク酸ナトリウム点鼻剤との比較試験
説明
通年性アレルギー性鼻炎患者233例を対象にR50547 0.025%点鼻剤 (L群), 1日4 回投与の有効性, 安全性および有用性をクロモグリク酸ナトリウム2%点鼻剤 (S群), 1日6回投与を対照とした単盲検比較法にて検討した.<BR>最終全般改善度では, L群はS群に比し, 有意に高い改善度を示した (U検定:p< 0.05). また, 「中等度改善」以上ではL群60.2%, S群45.4%であり, 約IS%の差が認められた. 概括安全度では両群間に有意な差はみられなかつた. 最終全般改善度および概括安全度より評価した有用度においても, L群はS群に比し, 有意に高い有用度を示した (U検定:p<0.05).<BR>以上より, R50547点鼻剤はクロモグリク酸ナトリウム点鼻剤と比較し, 優れた臨床効果と同程度の高い安全性を有し, 通年性アレルギー性鼻炎に対し有用性の高い薬剤であることが確認された.
収録刊行物
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- 耳鼻と臨床
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耳鼻と臨床 41 (2Supplement1), 381-403, 1995
JIBI TO RINSHO KAI
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詳細情報 詳細情報について
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- CRID
- 1390001205499064320
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- NII論文ID
- 130004404149
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- ISSN
- 04477227
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
