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Combination chemotherapy with Docetaxel, Cisplatin, and TS-1 for head and neck cancer
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- Fujii Masato
- Department of Otolaryngology, Tokyo National Medical Center
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- OZAWA Hiroyuki
- Department of Otolaryngology, Tokyo National Medical Center
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- MATSUNAGA Tatsuo
- Department of Otolaryngology, Tokyo National Medical Center
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- MASUDA Kanako
- Department of Otolaryngology, Tokyo National Medical Center
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- MIZUTARI Kunio
- Department of Otolaryngology, Tokyo National Medical Center
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- TOMITA Toshiki
- Department of Otolaryngology, Keio University
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- YAMAGUCHI Hiroshi
- Department of Otolaryngology, Keio University
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- TAGAWA Takamasa
- Department of Otolaryngology, Keio University
Bibliographic Information
- Other Title
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- 頭頸部癌に対するドセタキセル、シスプラチン、TS-1併用療法の検討
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Description
We conducted the phase I study of the combination chemotherapy with Docetaxel (D), Cisplatin (C) and TS-1 (T) for head and neck cancer. D and C were administered at day 8 and T was orally administered from day 1 to day 14. The second course was started at day 29 except for NC cases. The dose of TS-1 was 80mg/m2/day for every levels. Six cases were enrolled for each level 1 (D: 30, C: 30mg/m2) and level 2 (D: 40, C: 30). DLT was defined as grade 4 hematological toxicity, grade 3 non-hematological toxicity, and more than 7 days delay of TS-1 administration. Two cases showed DLT at level 1 and 3 cases showed DLT, febrile neutropenia and dierrhea. The level 2 was considered MTD. The combination of D, C, and T seemed toxic. Adequate dose of D and C could not administered with the dose of T, 80mg/m2. We will again make assessment for the combination regimen with lower dose of T for higher dose of D and C in future.
Journal
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- OTOLOGIA FUKUOKA
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OTOLOGIA FUKUOKA 50 (5Supplement1), S14-S18, 2004
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Details 詳細情報について
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- CRID
- 1390001205499693312
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- NII Article ID
- 130004404896
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- ISSN
- 04477227
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed