Occurrence of Spontaneous Tumors in a Newly Established Milk Agent-Free Substrain C3HeB/Os

AKAMATSU Yasuyuki, IKEGAMI Ryoichi, WATANABE Koji, SAHEKI Kazuhiro

doi:10.1538/expanim1957.18.1_17

Since December, 1963, a substrain of C3HeB mice has been established at the Institute for Cancer Research, Osaka University Medical School. This strain has been maintained by broth-er-sister mating and at the present, July, 1968 has reached the 20th generation. The present paper described occurrence of spontaneous tumors of this substrain ; mammary tumors (2.1%), pulmonary adenoma (3.1%), abdominal lymphoma (6.2%), ovarian cysts (2.1%) in females and hepatomas (14.3%), abdominal lymphomas (4. 0%) in males. This substrain was susceptible to the milk facter but did not pass to their offspring. The susceptibility to the agent was examined by foster-nursing on C3H/HeOs mother which carry the agent showing high incidence of mammary tumor (92.5% for breeders, 78.8% for virgins) . The foster-nursed C3HeB mice on C3H showed high incidence of mammary tumor (81.3%) but did not pass the agent efficently to their off springs with decreased incidence (42.9%) . On the other hand, foster-nursed C3H mice on C3HeB developed mammary tumors with a sig-nificantly low incidence (15.8% ), but passed the agent to the offsprings which showed high ir cidence of mammary tumors (75.0%) .

Occurrence of Spontaneous Tumors in a Newly Established Milk Agent-Free Substrain C3HeB/Os

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