Pathophysiology and evaluation of autophagy in organ preservation

DOI
  • Fukai Moto
    Department of Transplant Surgery, Graduate School of Medicine, Hokkaido Univ.
  • Shimada Shingo
    Department of Gastroenterological Surgery 1, Graduate School of Medicine, Hokkaido Univ.
  • Wakayama Kenji
    Department of Gastroenterological Surgery 1, Graduate School of Medicine, Hokkaido Univ.
  • Ishikawa Takahisa
    Department of Gastroenterological Surgery 1, Graduate School of Medicine, Hokkaido Univ.
  • Shimamura Tsuyoshi
    Division of Organ Transplantation, Hokkaido University Hospital.
  • Yamashita Kenichiro
    Department of Transplant Surgery, Graduate School of Medicine, Hokkaido Univ.
  • Taketomi Akinobu
    Department of Gastroenterological Surgery 1, Graduate School of Medicine, Hokkaido Univ.

Bibliographic Information

Other Title
  • 臓器保存におけるオートファジーの病態と評価法

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Description

To establish the resuscitation and recovery of the marginal organs, we should understand the biological responses within the graft, such as hypothermia, hypoxia, fasting, oxidative stress, mitochondrial dysfunction, Ca2+ overload, infl ammation, and others. We should enhance the protective responses and inhibit the detrimental responses before harvest, during storage, during machine perfusion, and after reperfusion. Autophagy plays a protective role via degradation of damaged organelles, and provides materials to reconstitute the organelles and fuel to maintain homeostasis. However, excess autophagy (self-eating) exacerbates cellular injury. Regulation of autophagy by pharmaceuticals and by surgical interventions would help organ resuscitation and recovery. Accordingly, the author reviewed the role of autophagy in the hepatic ischemia and reperfusion injury, and the recommended methods to evaluate autophagic flux.

Journal

  • Organ Biology

    Organ Biology 22 (2), 128-133, 2015

    The Japan Society for Organ Preservation and Biology

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