Pathophysiology and evaluation of autophagy in organ preservation
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- Fukai Moto
- Department of Transplant Surgery, Graduate School of Medicine, Hokkaido Univ.
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- Shimada Shingo
- Department of Gastroenterological Surgery 1, Graduate School of Medicine, Hokkaido Univ.
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- Wakayama Kenji
- Department of Gastroenterological Surgery 1, Graduate School of Medicine, Hokkaido Univ.
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- Ishikawa Takahisa
- Department of Gastroenterological Surgery 1, Graduate School of Medicine, Hokkaido Univ.
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- Shimamura Tsuyoshi
- Division of Organ Transplantation, Hokkaido University Hospital.
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- Yamashita Kenichiro
- Department of Transplant Surgery, Graduate School of Medicine, Hokkaido Univ.
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- Taketomi Akinobu
- Department of Gastroenterological Surgery 1, Graduate School of Medicine, Hokkaido Univ.
Bibliographic Information
- Other Title
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- 臓器保存におけるオートファジーの病態と評価法
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Abstract
To establish the resuscitation and recovery of the marginal organs, we should understand the biological responses within the graft, such as hypothermia, hypoxia, fasting, oxidative stress, mitochondrial dysfunction, Ca2+ overload, infl ammation, and others. We should enhance the protective responses and inhibit the detrimental responses before harvest, during storage, during machine perfusion, and after reperfusion. Autophagy plays a protective role via degradation of damaged organelles, and provides materials to reconstitute the organelles and fuel to maintain homeostasis. However, excess autophagy (self-eating) exacerbates cellular injury. Regulation of autophagy by pharmaceuticals and by surgical interventions would help organ resuscitation and recovery. Accordingly, the author reviewed the role of autophagy in the hepatic ischemia and reperfusion injury, and the recommended methods to evaluate autophagic flux.
Journal
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- Organ Biology
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Organ Biology 22 (2), 128-133, 2015
The Japan Society for Organ Preservation and Biology
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Keywords
Details 詳細情報について
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- CRID
- 1390001205511730176
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- NII Article ID
- 130005142913
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- ISSN
- 21880204
- 13405152
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed