CARCINOGENICITY OF 2-(2-FURYL)-3-(5-NITRO-2-FURYL) ACRYLAMIDE (AF-2) FED TO FEMALE SPRAGUE-DAWLEY RATS

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  • COHEN Samuel M.
    First Department of Pathology, Nagoya City University Medical School
  • 市川 正孝
    熊本大学薬学部 Division of Clinical Oncology, Department of Human Oncology, University of Wisconsin Center for Health Sciences
  • BRYAN George T.
    Division of Clinical Oncology, Department of Human Oncology, University of Wisconsin Center for Health Sciences

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タイトル別名
  • Carcinogenicity of 2 2 Furyl 3 5 nitro

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The carcinogenicity of 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (AF-2) was investigated by administering it orally to Sprague-Dawley female weanling rats in a grain diet at a dose of 0.2% for 46 weeks, followed by 20 weeks of unmedicated control diet. The total mean cumulative dose of AF-2 was 10.1g (41.6mmol) per rat during the 46 weeks of the experiment. Weight gain of rats fed AF-2 was comparable to that of unmedicated control rats. Survival of rats fed AF-2 was 52±12 (SD) weeks compared to 65±5 weeks for the unmedicated controls (P<0.001). Twenty-four of 29 rats fed AF-2 developed multiple breast tumors, 15 of which were adenocarcinomas. Two of 29 unmedicated control rats had single fibroadenomas of the breast.

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