CHRONIC TOXICITY OF 2-(2-FURYL)-3-(5-NITRO-2-FURYL) ACRYLAMIDE (AF-2) IN MICE, WITH SPECIAL REFERENCE TO CARCINOGENICITY IN THE FORESTOMACH
書誌事項
- タイトル別名
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- Chronic Toxicity of 2 2 Furyl 3 5 nitro
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Chronic toxicity of 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (AF-2), which had been widely used in Japan as a food additive, was studied in both sexes of ICR/JCL mice by feeding a diet containing AF-2 in a concentration of 0.4% or 0.08%. The experiments confirmed its definite carcinogenicity in the forestomach, with dose dependency; more than 70% of mice fed the higher dose developed tumors, the majority of which were squamous cell carcinomas with metastatic growths, whereas, with a lower dose, fewer tumors occurred, following a longer latent period. In addition, possible leukemogenicity was suggested by a higher incidence in AF-2-fed females (10.8%) over that in control females (3.2%). The development of non-neoplastic lesions in the liver and kidneys, and of amyloidosis in various organs was also observed in some of AF-2-fed mice.
収録刊行物
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- GANN Japanese Journal of Cancer Research
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GANN Japanese Journal of Cancer Research 68 (6), 825-828, 1977
日本癌学会
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詳細情報 詳細情報について
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- CRID
- 1390001205529326080
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- NII論文ID
- 40000528964
- 130006409780
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- NII書誌ID
- AN00045888
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- NDL書誌ID
- 1917534
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- ISSN
- 0016450X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可