Synthesis of Dimethyl Quercetin Derivative for the Purpose of Enhanced Radical-Scavenging Activity
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- Imai Kohei
- National Institute of Health Sciences Shibaura Institute of Technology
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- Nakanishi Ikuo
- National Institute of Radiological Sciences
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- Takagaki Ryohei
- National Institute of Health Sciences
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- Okuda Haruhiro
- National Institute of Health Sciences
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- Ozawa Toshihiko
- National Institute of Radiological Sciences Yokohama College of Pharmacy
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- Matsumoto Ken-ichiro
- National Institute of Radiological Sciences
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- Nakamura Asao
- Shibaura Institute of Technology
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- Fukuhara Kiyoshi
- National Institute of Health Sciences
Bibliographic Information
- Other Title
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- ラジカル消去活性の増強を目的としたジメチルケルセチン誘導体の合成
Description
Oxidative stress is important in the pathogenesis of coronary diseases, brain dysfunction and cancer. Previously, we have synthesized planar catechin derivative (PC) by which catechol and chroman moieties in (+)-catechin structure are constrained to be planar. PC is about 5-fold larger than that for (+)-catechin. The radical-scavenging activity of PC is enhanced by way of introduction of electron donating isopropyl moiety that results in the stabilizaition of radical cation. In this study, we have synthesized quercetin derivative for the purpose of enhanced radical scavenging activity. Quercetin derivative that has either mono or di methyl moiety at catechol was synthesized. The radical scavenging activities of them were examined using galvinoxyl radical as an oxyl radical species, showing the stronger radical scavenging activities than quercetin.
Journal
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- Proceedings of the Symposium on Progress in Organic Reactions and Syntheses
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Proceedings of the Symposium on Progress in Organic Reactions and Syntheses 37 (0), 117-117, 2011
Division of Organic Chemistry, The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001205633902080
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- NII Article ID
- 130006996073
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed