活性メチレン化合物の選択的臭素化反応

DOI

書誌事項

タイトル別名
  • Chemoselective Bromination of Active Methylene Compounds

抄録

Halogenated active methylene compounds are important synthetic intermediates owing to their high reactivity for the nucleophilic substitution. A number of methods have previously been described in the literature for the haloganation of active methylene compounds, however, most of them have serious disadvantage. We now report the novel chemoselective bromination of active methylene compounds using potassium bromide, hydrogen peroxide and hydrochloric acid. The monobrominated active methylene compounds were quantitatively obtained from the reaction of the active methylene compounds with potassium bromide and hydrogen peroxide in toluene and hydrochloric acid. Ester bonds, amide bonds and aromatic rings were not affected at all under the reaction conditions.

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390001205634649216
  • NII論文ID
    130006997085
  • DOI
    10.14895/hannou.31.0.186.0
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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