カエル終板ニコチン性アセチルコリン受容体のクラーレと免疫反応による超微細構造の可視化

DOI

書誌事項

タイトル別名
  • Ultrastructural visualization of the transmembrane nicotinic AChR of frog motor endplate by means of an immunochemical reaction with d-tubocurarine.

抄録

D-tubocurarine (d-TC) was used to block the synaptic transmission of frog neuromuscular junction. A recently discovered avidity of IgG for d-TC and also for other quaternary ammonium compounds (Tsuji et al 2003) was used to visualize the d-TC bound to the nicotinic acetylcholine receptor (nAChR) by means of an immunochemical reaction (immunoperoxidase). Regularly disposed transmembrane rod-like structures were observed through the postsynaptic membrane and interpreted as a staining of the interior side of the nAChR. Reference: Tsuji, S. et al (2003) Binding avidity of immunoglobulin G for acetylcholine. Biomed Res 24: 217-221 [J Physiol Sci. 2007;57 Suppl:S151]

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詳細情報 詳細情報について

  • CRID
    1390001205728331776
  • NII論文ID
    130005449027
  • DOI
    10.14849/psjproc.2007.0_151_4
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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