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- Terada Masahiro
- Department of Biochemistry, Meiji Pharmaceutical University
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- Araki Makoto
- Department of Biochemistry, Meiji Pharmaceutical University Department of Molecular Biology, School of Pharmacy, Iwate Medical University
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- Ashibe Bunichiro
- Department of Biochemistry, Meiji Pharmaceutical University Central Research Center, Yomeishu Seizo Co., Ltd
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- Motojima Kiyoto
- Department of Biochemistry, Meiji Pharmaceutical University
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説明
The peroxisome proliferator-activated receptor (PPAR) subtype specificity of GW501516, a well-known PPARδ-specific agonist, was studied by examining its effects on the expression of endogenous genes in primary hepatocytes and the liver of wild-type and PPARα-null mice. GW501516, like the PPARα-specific agonist Wy14,643, induced the expression of several PPAR target genes in a dose-dependent manner but this action was mostly absent in the cells and liver of PPARα-null mice. Results indicated that GW501516 acts as an efficient PPARα activator in the mouse liver.
収録刊行物
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- Drug Discoveries & Therapeutics
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Drug Discoveries & Therapeutics 5 (4), 176-180, 2011
特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会