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- 松崎 史夫
- 大阪大学医学部小児科学教室
書誌事項
- タイトル別名
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- THE ANTAGONISTIC ACTION OF HOMOPANTOTHENIC ACID AGAINST PANTOTHENIC ACID
- ホモパントテンサン ノ パントテンサン キッコウ サヨウ ニ ツイテ
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The action of homopantothenic acid, HOCH_2C(CH_3)_2CHOHCONH(CH_2)_3COOH, a derivative of γ-aminobutyric acid, and its hydroxy-forms was examined using lactobacilli and chick. These compounds showed a pronounced competitive antagonistic action for Lactobacillus arabinosus 17-5 and Leuconostoc mesenteroides P-60. When the 50% growth inhibition of homopantothenic acid was used as the index, an inhibition ratio of 150 was obtained. In the chick given 1mg/kg a day of pantothenic acid, oral administration of more than 2g/kg of homopantothenic acid induced pantothenic acid deficiency and reduction of liver CoA. These changes could be reversed by administration of pantothenic acid. This antagonistic effct of homopantothenic acid against pantothenic acid would be attributed to an inhibitory action in the pathway of biosynthesis from pantothenic acid to CoA.
収録刊行物
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- ビタミン
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ビタミン 32 (2), 245-259, 1965
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390001205784578560
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- NII論文ID
- 110002865162
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 8423925
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可