生体異物に対するビタミンEの代謝応答 : コレステロール代謝との関連を中心として

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タイトル別名
  • Influence of Dietary Xenobiotics on The Metabolism of Vitamin E with Special Reference to Cholesterol Metabolism
  • セイタイ イブツ ニ タイスル ビタミン E ノ タイシャ オウトウ コレステ

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Effects of dietary addition of some xenobiotics on the metabolism of α-tocopherol in rats were studied with special reference to cholesterol metabolism. Dietary xenobiotics including PCB, DDT, Chloretone, phenobarbital, etc. caused an increase in serum α-tocopherol and cholesterol. The effects of dietary PCB on serum and tissue levels of α-tocopherol were influenced with dietary protein and copper. The increases in serum α-tocopherol and cholesterol due to the chemicals were attributed to the increases in the fraction of high-density-lipoproteins (HDL). Dietary PCB and Chloretone caused an increase in apparent absorption of α-tocopherol. Dietary clofibrate depressed the increases in serum and tissue α-tocopherol, and serum cholesterol and also suppressed the increase in apparent absorption of α-tocopherol by Chloretone. These results suggest that the increase in serum cholesterol due to xenobiotics relates to the increase in serum and tissue α-tocopherol. As well as xenobiotics, feeding of cystine excess and histidine excess diets which are known to cause hypercholesterolemia also increased serum α-tocopherol.

収録刊行物

  • ビタミン

    ビタミン 66 (1), 25-34, 1992

    公益社団法人 日本ビタミン学会

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