書誌事項
- タイトル別名
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- Synthesis of Dibenzo [a, d] cycloheptenylacetic Acids
- Dibenzo〔a,d〕cycloheptene酢酸誘導体の合成
- Dibenzo a d cycloheptene サクサン ユウドウタイ ノ
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抄録
10, 11-Dihydro-10-oxo-5H-dibenzo [a, d] cycloheptenylacetic acids (2a-c) and 11-oxo analogs (2d-f) were prepared from the corresponding diphenylmethanediacetic acids by cyclization. 2-(10, 11-Dihydro-11-oxo-5H-dibenzo [a, d] cyclohepten-2-yl) propionic acid was also prepared from its acetic acid derivative (2e) in four steps. Their antiinflammatory and ulcerogenic effects were examined. Some of them showed potent antiinflammatory activity in carrageenin rat paw edema and weaker effect than indomethacin in causing gastrointestinal lesions.
収録刊行物
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- 薬学雑誌
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薬学雑誌 101 (7), 614-628, 1981
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206126914816
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- NII論文ID
- 110003650194
- 130007274408
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 2356471
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- データソース種別
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- JaLC
- NDL
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