書誌事項
- タイトル別名
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- The Effects of Kampo-Formulation and the Constituting Crude Drugs, Prescribed for the Treatment of Peptic Ulcer on H,K-ATPase Activity
- イ シッカン ニ ハンヨウ サレル カンポウ ホウザイ オヨビ コウセイ ショウヤク エキス ショウヤク ガンユウ セイブン ノ H K ATPase カッセイ ニ オヨボス エイキョウ
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抄録
We studied the effects of 17 kinds of Kampo-formulations prescribed for the treatment of peptic ulcer on H,K-ATPase activity. The activity was strongly inhibited by San-o-shashin-to (三黄瀉心湯, IC50=82 μg/ml), Bukuryo-in (茯苓飲, IC50=110 μg/ml), Shakuyaku-kanzo-to (芍薬甘草湯, IC50=170 μg/ml), Hange-koboku-to (半夏厚朴湯, IC50=290 μg/ml), Dai-saiko-to (大柴胡湯, IC50=340 μg/ml), Irei-san (胃苓散, IC50=380 μg/ml) than other Kampo-formulations. Among the 17 kinds of crude drugs contained in these Kampo-formulation, Rhei Rhizoma, Coptidis Rhizoma, Glycyrrhiza Radix, Cinnamomi Cortex, and Poria have notable inhibitory effects (IC50=19∼57 μg/ml). H,K-ATPase activity was inhibited by sennoside A (Rhei Rhizoma), sennoside B (Rhei Rhizoma), ergosterol (Poria), coptisine (Coptidis Rhizoma), glycyrrhizin (Glycyrrhiza Radix), glycyrrhetic acid (Glycyrrhiza Radix), gallic acid (Cinnamomi Cortex) in the 21 components of these crude drugs (IC50=1.6∼7.9×10-4M). The inhibition of San-o-shashin-to and Bukuryo-in is considered to be mainly attributed to Rhei Rhizoma and Poria, respectively. The anti-gastric ulcer effects of San-o-shashin-to and Bukuryo-in may be ascribed to the inhibition of H,K-ATPase activity.
収録刊行物
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- 薬学雑誌
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薬学雑誌 121 (2), 173-178, 2001-02-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206128132736
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- NII論文ID
- 110003661154
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- NII書誌ID
- AN00284903
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- COI
- 1:CAS:528:DC%2BD3MXnsFeqtA%3D%3D
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 5650759
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- PubMed
- 11218732
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可