Vasorelaxant Activity of Caffeic Acid Derivatives from Cichorium intybus and Equisetum arvense

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Other Title
  • キクニガナ及びスギナより得られたカフェー酸エステルの血管平滑筋弛緩作用
  • キクニガナ及びスギナより得られたカフェ一酸エステルの血管平滑筋弛緩作用
  • キクニガナ オヨビ スギナ ヨリ エラレタ カフェ 1サン エステル ノ ケッカン ヘイカツキン シカン サヨウ

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Abstract

The vasorelaxant activities of chicoric acid (Compound 1) from Cichorium intybus and dicaffeoyl-meso-tartaric acid (Compound 2) from Equisetum arvense L. in isolated rat aorta strips were studied. Compound 1 is a diester composed of (S,S)-tartaric acid and caffeic acid, and 2 is composed of its meso type. Both 1 and 2 showed slow relaxation activity against norepinephrine (NE)-induced contraction of rat aorta with/without endothelium. These compounds did not affect contraction induced by a high concentration of potassium (60 mM K+), while they inhibited NE-induced vasocontraction in the presence of nicardipine. These results show that the inhibition by 1 and 2 of NE-induced vasocontraction is due to a decrease in calcium influx from the extracellular space caused by NE. In addition, dicaffeoyl tartaric acids showed vasorelaxant activity, regardless of their stereochemistry.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 123 (7), 593-598, 2003

    The Pharmaceutical Society of Japan

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