Azulene関連化合物の研究(第3報)Acylaminoguaiazulene類の合成と抗潰瘍作用

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タイトル別名
  • Studies on the Compounds related to Azulene. III. Synthesis and Antiulcer Activity of Acylaminoguaiazulenes
  • Azulene関連化合物の研究-3-Acylaminoguaiazulene類の合成と抗潰瘍作用
  • Azulene カンレン カゴウブツ ノ ケンキュウ 3 Acylaminog

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抄録

Acylaminoguaiazulenes, mainly dicarboxylic acid monoguaiazulenamides, were synthesized and their antiulcer activity was investigated by Shay ulceration method in the rat. Dicarboxylic acid monoguaiazulenamides, particularly aliphatic dicarboxylic acid monoguaiazulenamides, showed a high antiulcer activity. Compounds (1g, h) were more effective than guaiazulene in both administrations (s.c. and i.d.). Structure-activity relationship of these compounds was briefly discussed.

収録刊行物

  • 薬学雑誌

    薬学雑誌 101 (11), 1048-1052, 1981

    公益社団法人 日本薬学会

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