Development of Redox Metabolic Imaging Using Endogenous Molecules

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  • Hyodo Fuminori
    Innovation Center for Medical Redox Navigation, Kyushu University
  • Ito Shinji
    Innovation Center for Medical Redox Navigation, Kyushu University
  • Eto Hinako
    Innovation Center for Medical Redox Navigation, Kyushu University
  • Nakaji Tomoko
    Innovation Center for Medical Redox Navigation, Kyushu University
  • Yasukawa Keiji
    Innovation Center for Medical Redox Navigation, Kyushu University Graduate School of Pharmaceutical Science Kyushu University
  • Kobayashi Ryoma
    Innovation Center for Medical Redox Navigation, Kyushu University
  • Utsumi Hideo
    Innovation Center for Medical Redox Navigation, Kyushu University

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Other Title
  • 生体内分子・医薬品を用いた新たな代謝イメージング法の開発
  • Symposium Review 生体内分子・医薬品を用いた新たな代謝イメージング法の開発
  • Symposium Review セイタイナイ ブンシ ・ イヤクヒン オ モチイタ アラタ ナ タイシャ イメージングホウ ノ カイハツ

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Abstract

 Redox metabolism plays a central role in maintaining homeostasis in living organisms. The electron transfer system in mitochondria produces ATP via endogenous redox molecules such as flavin mononucleotide (FMN), flavin adenine dinucleotide (FAD), and coenzyme Q10 (CoQ10), which have flavin or quinone moieties. One-electron transfer reactions convert FMN, FAD, and CoQ10 to the free radical intermediates FMNH and FADH, and CoQ10H, respectively. Dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) allows us to visualize free radicals in vitro and in vivo. We present a spectroscopic imaging technology with DNP-MRI, which enables the imaging of multiple free radical intermediates such as FADH and CoQH. DNP-MRI can also identify various endogenous free radical intermediates derived from redox transformations.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 136 (8), 1107-1114, 2016-08-01

    The Pharmaceutical Society of Japan

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