Stability Studies on Nafamstat Mesilate in Aqueous Solution. II. Studies on Photostability of Nafamstat Mesilate

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Other Title
  • Nafamstat Mesilateの水溶液中での安定性に関する研究(第2報)光安定性に関する検討
  • Nafamstat Mesilateの水溶液中での安定性に関する研究-2-光安定性に関する検討
  • Nafamstat Mesilate ノ スイヨウエキチュウ デ ノ アンテイ

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Description

The decomposition compound formed by xenon irradiation of nafamstat mesilate in aqueous solution and its kinetics were studied and the following findings were obtained. Nafamstat mesilate was decomposed by xenon irradiation to form 4-guanidinobenzoic acid (PGBA), 6-amino-2-naphthol (AN) and compound II having yellow color. The structure of the compound II was studied in comparison with nafamstat mesilate by chemical and physical methods and shown to be an amide type compound of PGBA and AN. Photodemposition reaction of nafamstat mesilate was found to follow the pseudo-second order reaction.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 105 (5), 470-474, 1985

    The Pharmaceutical Society of Japan

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