Nafamstat Mesilateの水溶液中での安定性に関する研究(第2報)光安定性に関する検討

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タイトル別名
  • Stability Studies on Nafamstat Mesilate in Aqueous Solution. II. Studies on Photostability of Nafamstat Mesilate
  • Nafamstat Mesilateの水溶液中での安定性に関する研究-2-光安定性に関する検討
  • Nafamstat Mesilate ノ スイヨウエキチュウ デ ノ アンテイ

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説明

The decomposition compound formed by xenon irradiation of nafamstat mesilate in aqueous solution and its kinetics were studied and the following findings were obtained. Nafamstat mesilate was decomposed by xenon irradiation to form 4-guanidinobenzoic acid (PGBA), 6-amino-2-naphthol (AN) and compound II having yellow color. The structure of the compound II was studied in comparison with nafamstat mesilate by chemical and physical methods and shown to be an amide type compound of PGBA and AN. Photodemposition reaction of nafamstat mesilate was found to follow the pseudo-second order reaction.

収録刊行物

  • 薬学雑誌

    薬学雑誌 105 (5), 470-474, 1985

    公益社団法人 日本薬学会

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