書誌事項
- タイトル別名
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- Induction of Biological Activities by Chemically Modified Subfragments from Human Serum IgG and Their Application to Development of Medicine
- ヒト ケッセイ IgG ノ カガク シュウショク ニヨル シンキ カッセイ ノ
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説明
Immunoglobulin G (IgG) is an important protein in humoral immunity. After IgG binds to the specific foreign antigen, IgG-antigen complexes are eliminated either by making it easier for a phagocytic cell to ingest them or by activating a complement system. We found that the carboxyamidemethylated subfragments obtained from human serum IgG by reduction and alkylation of its interchain disulfide bonds, have anti-ulcerogenic, anti-inflammatory and antiallergic activities, while no activity was recognized in the original IgG. On the other hand, some saturated and unsaturated fatty acids generally existing in microorganisms were found to have anti-inflammatory and anti-ulcerogenic activities. As the application of these researches, we synthesized hybrid compounds from sulfur-containing amines and fatty acids to make a lead compound for developing a new medicine. In this review, the experimental process will be discussed.
収録刊行物
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- 薬学雑誌
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薬学雑誌 116 (5), 374-387, 1996
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206154898688
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- NII論文ID
- 110003649031
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 3961438
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可
