漢薬・炮附子の薬理活性研究(第1報)アジュバント関節炎に及ぼす炮附子水抽出エキスの影響

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タイトル別名
  • Pharmacological Study on Aconiti Tuber. I. Effect of Water Extract from Aconiti Tuber on Adjuvant-Induced Arthritis
  • 漢薬・炮附子の薬理活性研究-1-アジュバント関節炎に及ぼす炮附子抽出エキスの影響
  • カンヤク ホウブシ ノ ヤクリ カッセイ ケンキュウ 1 アジュバント カンセ

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抄録

Anti-inflammatory activity of a hot water extract (A-ext) of Aconiti Tuber (Aconitum calmicaeli DEBX.) has been studied by using various experimental models. The succesive administration of A-ext from the day of injection of adjuvant agent or 5 d after the injection it significantly inhibited the adjuvant-induced arthritis developed in the primary and secondary lesions in rats. However, when A-ext was administered from 11 d after the injection of adjuvant, the arthritic paw edema was not reduced. A-ext did not inhibit an acetic acid-induced increase in vascular permeability in mice and carrageenin-induced paw edema in rats. A-ext inhibited cotton pellet-induced granuloma in rats, but did not suppress the weight of thymus and adrenal gland. In vitro experiment, A-ext contracted the isolated ileum of guinea pig, but the contractive activity was reduced by pretreatment of anti-histamine agent, diphenhydramine, but not by pretreatment of papaverine or atropine. A-ext did not release histamine from peritoneal mast cell. These results suggest that A-ext prevents the adjuvant-induced arthritis and bas a histamine-like effect.

収録刊行物

  • 薬学雑誌

    薬学雑誌 110 (1), 16-26, 1990

    公益社団法人 日本薬学会

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