書誌事項
- タイトル別名
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- Effects of Various Fatty Acids on Stabilization of Rat Erythrocyte and Carrageenin-induced Edema
- ラット セッケッキュウ マク アンテイカ オヨビ カラゲニン フシュ ニ タイ
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Anti-inflammatory effect of C10-C20 saturated fatty acids was examined by using heat-induced hemolysis, hypotonic hemolysis, heat-induced denaturation of bovine serum albumin (BSA), and carrageenin-induced paw edema as the experimental systems. 1) Several fatty acids, including C13 : 0 to C17 : 0, were found to protect erythrocytes from heat-induced hemolysis, and C12 : 0 to C16 : 0 significantly inhibited hypotonic hemolysis in vitro. 2) All fatty acids tested showed a significant effect on heat-induced denaturation of BSA at a concentration of 5.0 μg/ml in vitro, but C16 : 0 methyl ester did not show any inhibitory effect at the same concentration. 3) Palmitic acid, its methyl ester, and oleic acid suppressed carrageenin-induced paw edema in rats by oral administration at the dosage of 200 mg/kg, but C16 : 0 methyl ester did not suppress it by intraperitoneal injection. 4) In adrenalectomized rats, palmitic acid also suppressed carrageenin-induced paw edema. 5) Palmitic acid inhibited the granuloma formation caused by felt-pellet at the dose of 100 mg/kg/day (oral) for 5 days, but did not show a significant effect on either exudation into the granuloma pouch or on formation of pouch wall.
収録刊行物
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- 薬学雑誌
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薬学雑誌 97 (11), 1246-1252, 1977
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206216746496
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- NII論文ID
- 130007287387
- 110003652474
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 1916531
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- NDL
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