EFFECT OF N- (3-PHENYL-2-PROPENYL) -1-DEOXYNOJIRIMYCIN ON THE LECTIN BINDING TO HIV-1 GLYCOPROTEINS
書誌事項
- タイトル別名
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- EFFECT OF <I>N</I>- (3-PHENYL-2-PROPENYL) -1-DEOXYNOJIRIMYCIN ON THE LECTIN BINDING TO HIV-1 GLYCOPROTEINS
抄録
The effect of N- (3-phenyl-2-propenyl) -1-deoxynojirimycin (ppDNM) on the lectin binding to HIV-1 glycoprotein was analyzed by using biotinylated lectins of various sugar specificities as probes. ppDNM potentially inhibited HIV-1-induced syncytium formation and viral infectivity of HIV-1 without cytotoxicity. The lectin binding assay showed that ppDNM treatment reduced Con A binding to gp120 of HIV-1.
収録刊行物
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- Ｊａｐａｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ ａｎｄ Ｂｉｏｌｏｇｙ
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Ｊａｐａｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ ａｎｄ Ｂｉｏｌｏｇｙ 43 (3), 75-87, 1990
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会