Genetic Analysis of HIV-1 in Japan: a Comprehensive Analysis of Donated Blood
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- Matsumoto Chieko
- Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society
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- Shinohara Naoya
- Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society
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- Sobata Rieko
- Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society
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- Uchida Shigeharu
- Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society
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- Satake Masahiro
- Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society
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- Tadokoro Kenji
- Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society
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抄録
In Japan, the number of human immunodeficiency virus (HIV)-1 infections remains relatively low; nevertheless, the annual incidence of HIV-1 infection has not decreased. New infections remain a great concern, and an improved understanding of epidemiological trends is critical for public health. The env C2V3 and pol sequences of HIV-1 RNA from 240 early (1996–2001) and 223 more recent (2010–2012) blood donations were used to compare the distribution of virus subtypes and to generate phylogenetic trees. Subtype B was clearly predominant in both early and more recent donations (both were 88.3%), and CRF01_AE was the second most common subtype. Phylogenetic analysis revealed a peculiar epidemiological transition. Compared to early subtype B isolates from 2 major endemic areas (Tokyo and Osaka), the more recent subtype B isolates formed fewer tight clusters in phylogenetic trees (from 8 to 2 clusters in Tokyo and 5 to zero clusters in Osaka). Furthermore, mixing of HIV-1 infections between these 2 endemic areas appear to increase. Analysis of phylogenetic trees suggested that local outbreaks have become smaller in Japan; however, intermixing of viral types between these 2 areas was more evident in the more recent samples.
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 70 (2), 136-142, 2017
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001206239644160
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- NII論文ID
- 130005475409
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 028079634
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- PubMed
- 27357980
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可