Lack of Association between <i>BSG</i> Polymorphisms and Cerebral Malaria
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- Naka Izumi
- Faculty of Medicine, University of Tsukuba
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- Patarapotikul Jintana
- Faculty of Tropical Medicine, Mahidol University
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- Hananantachai Hathairad
- Faculty of Tropical Medicine, Mahidol University
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- Ohashi Jun
- Faculty of Medicine, University of Tsukuba
Bibliographic Information
- Other Title
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- Lack of Association between BSG Polymorphisms and Cerebral Malaria
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Abstract
The Oka blood group antigen basigin (BSG or CD147) is an erythrocyte receptor for the PfRh5 protein from Plasmodium falciparum. A recent study has shown that the PfRh5–BSG interaction is essential for erythrocyte invasion by P. falciparum. In this study, 6 SNPs in the BSG gene were investigated in 312 adult patients with P. falciparum malaria (109 cerebral malaria and 203 mild malaria patients) living in northwest Thailand. To examine the association between BSG SNPs and cerebral malaria, the allele and haplotype frequencies were compared in cerebral and mild malaria patients. Nonsynonymous SNPs were not assessed in the association analysis. The results showed that common BSG polymorphisms and haplotypes were not significantly associated with cerebral malaria. In conclusion, common SNPs in BSG do not influence the risk of cerebral malaria in the Thai population.
Journal
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 67 (6), 432-435, 2014
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
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Details 詳細情報について
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- CRID
- 1390001206241527296
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- NII Article ID
- 130004712734
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- NII Book ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL BIB ID
- 025937801
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- PubMed
- 25410557
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed