First Detection of an Escherichia coli Strain Harboring the mcr-1 Gene in Retail Domestic Chicken Meat in Japan
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- Ohsaki Yusuke
- Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine
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- Hayashi Wataru
- Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine
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- Saito Satomi
- Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine
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- Osaka Shunsuke
- Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine
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- Taniguchi Yui
- Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine
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- Koide Shota
- Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine
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- Kawamura Kumiko
- Department of Pathophysiological Laboratory Science, Nagoya University Graduate School of Medicine
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- Nagano Yukiko
- Department of Bacteriology, Nagoya University Graduate School of Medicine
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- Arakawa Yoshichika
- Department of Bacteriology, Nagoya University Graduate School of Medicine
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- Nagano Noriyuki
- Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine
書誌事項
- タイトル別名
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- First Detection of an <i>Escherichia coli</i> Strain Harboring the <i>mcr-1</i> Gene in Retail Domestic Chicken Meat in Japan
- First detection of Escherichia coli harboring mcr-1 gene from retail domestic chicken meat in Japan
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<p>Global spread of the plasmid-mediated colistin resistance gene, mcr-1 poses a challenge to public health because colistin is the last-line-of-defense against severe infections of multidrug-resistant Gram-negative bacteria. In Japan, a few studies have reported the prevalence of mcr-1 among food animal-derived Escherichia coli isolates, but the prevalence of mcr-1 in retail meats is not well known. We report here the first detection of mcr-1 in retail chicken meat. A total of 70 extended-spectrum beta-lactamase-producing E. coli isolates, recovered from retail chicken meats between August 2015 and June 2016, were screened for mcr-1. We found 1 CTX-M-1 beta-lactamase-producing E. coli isolate belonging to ST1684, phylogroup A. The mcr-1 gene was not located on an IncI1 plasmid encoding the blaCTX-M-1 gene. However, whole plasmid sequencing revealed that mcr-1 was located on an IncI2 plasmid. The sequences of the nikB-mcr-1-pap2-ydfA-topB region of the IncI2 plasmid in this study was almost identical to that of the previously described IncI2 plasmid, pECJS-61–63 present in E. coli isolated from pig feces in China, except for containing a synonymous mutation in the mcr-1 gene. Plasmid carrying the mcr-1 gene have not yet been identified in human isolates in Japan. Thus, strict monitoring or surveillance of colistin resistance among Gram-negative bacteria recovered from retail meat of food animals under colistin pressure, and humans, is crucial.</p>
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 70 (5), 590-592, 2017
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001206242143232
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- NII論文ID
- 130006096729
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 028534945
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- PubMed
- 28674313
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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