Carbenicillinに関する薬理学的研究

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タイトル別名
  • PHARMACOLOGICAL STUDIES ON CARBENICILLIN
  • Carbenicillin ニ カンスル ヤクリガクテキ ケンキュウ

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説明

Some Pharmacological actions of carbenicillin (disodium α-carboxybenzylpenicillin), a new semisynthetic penicillin, were investigated. No effects were obser ved on the blood pressure and respiration in anesthetized rabbit intravenously given carbenicillin 100 mg/kg; on the excised atrium of guinea-pig and heart of toad in 10-3g/ml carbenicillin concentration; and on the excised intestine of rabbit in 10-3g/ml. The perfused rabbit ear vessels was given no effect by carbenicillin 10-4 g/ml, but was slightly contracted by high concentration as 10-3-10-2 g/ml. Carbenicilli n had also no effects on the actions of adrenaline and acetylcholine in the blood pressure of rabbit, or on the actions of adrenaline, acetylcholine and histamine in the excised rabbit intestine. When carbenicillin was infused into the cisterna magna of rabbit or the cerebrum of m ouse, the convulsions were not typical and not specific. It is indicated that carbenicillin has almost no effects on the functions of autonomic nervous system, cardiovascular system, movement of smooth muscle and central nervous system. Furthermore, it is concluded that carbenicillin has less pharmacological actions than penicillin-G and other semisynthetic penicillins (phenoxypropyl-, phenoxyethyl-, aminobenzyl- and methylchlorophenylisoxazolyl-penicillin) except dimethoxyphenyl-penicillin.

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