新カナマイシンDKB (3', 4'-Dideoxykanamycin B) の抗菌作用

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タイトル別名
  • ANTIBACTERIAL EFFECTS OF DIDEOXYKANAMYCIN B ON GRAM NEGATIVE BACTERIA
  • シン カナマイシン DKB 3 , 4 -Dideoxykanamycin B ノ コウキン サヨウ

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抄録

Dideoxykanamycin B, a new aminoglycoside antibiotic showed the bactericidal effect on the gram-negative bacteria, as well as gentamicin. Short treatment of Escherichia coli B, Pseudomonas aeruginosa P 28 and P 29 with dideoxykanamycin B and gentamicin resulted in bleb-formation from the outer layer of the cell wall, and prolonged treatment caused lysis of the cells. These alterations may be interpreted that dideoxykanamycin B primarily acts to distort the molecular arrangement of the cell envelope.

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