Ｎｅｔｉｌｍｉｃｉｎとセフェム系抗生物質とのｉｎ　ｖｉｔｒｏ併用効果の検討

DOI

書誌事項

タイトル別名
  • In vitro synergistic effect of netilmicin and cephems.

抄録

The combined action of netilmicin (NTL) with latamoxef (LMOX), cefoperazone (CPZ), ceftizoxime (CZX), cefmenoxime (CMX) or ceftazidlme (CAZ) was studied against Escherichia coil, Serratia marcescens, Pseudomonas aeruginosa and Moraxella (Branhamella) catarrhalis. The following results were obtained<BR>1. The antibacterial activity of each antibiotic by itself against E. coil and M.(B.) catarrhaliswas strong.<BR>2. Synergistic action of NTL with each of LMOX, CPZ, CZX, CMX and CAZ was observed on all bacteria, especially S. marcescens and P. aeruginosa. The combination of NTL with CPZ was most effective.<BR>3. Bactericidal activity of NTL with LMOX or CAZ was observed on S. marcescens T-55 and P. aeruginosa E-2 at concentrations in which the respective drugs alone showed only bacteriostatic activity.<BR>4. Phase-contrast microscopic observation of P. aeruginosa E-2 demonstrated that the bacterial cells treated with LMOX or CAZ showed a filament-like form and those treated with NTL almost a normal form. In each combination lysed cells were observed.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390001206279155200
  • NII論文ID
    130004196702
  • DOI
    10.11250/chemotherapy1953.37.115
  • ISSN
    18845894
    00093165
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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