PHARMACOKINETICS OF CINOXACIN IN PATIENTS WITH IMPAIRED RENAL FUNCTION

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Other Title
  • 腎機能障害時におけるCinoxacinの血清中動態および尿中排泄動態に関する研究
  • ジン キノウ ショウガイジ ニ オケル Cinoxacin ノ ケッセイチュウ

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Abstract

The pharmacokinetics of cinoxacin, a new synthetic antibacterial agent, were examined in 6 healthy volunteers and 12 patients with different endogeneous creatinine clearances (Ccr) on the basis of a one-compartment open model. Each subject received a single 400mg oral dose of cinoxacin, and serum and urinary concentrations of free cinoxacin and cinoxacin conjugate were measured by a fluorometric method. The mean peak concentration of free cinoxacin in serum was achieved 3 hours after administration in normal subjects. The mean serum half-life of free cinoxacin was calculated for 66 minutes in normal subjects, and increased in patients along with increasing impairment of renal function. A significant correlation between the elimination rate constant and Ccr was demonstrated (p<0.001). In normal subjects, 62% of the drug was excreted in the urine as free cinoxacin within the first 12 hours, 95% as total cinoxacin including cinoxacin conjugate. The urinary excretion rate declined gradually in patients as a degree of renal impairment advanced.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 28 (Supplement4), 133-138, 1980

    Japanese Society of Chemotherapy

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