KW-1062に関する臨床的研究

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タイトル別名
  • CLINICAL STUDIES ON KW-1062
  • KW 1062 ニ カンスル リンショウテキ ケンキュウ

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KW-1062 is a new aminoglycoside antibiotic with potent antimicrobial activity against gram-negative bacteria.<BR>1. After a single intramusclar injection of 40 mg of KW-1062 to patients with impaired renal functions, serum levels were determined. In a patient with a creatinine clearance of 36 ml/min, the serum concentration reached to the peak after 2 hrs and fell down slowly to an undetectable level after 24 hrs. In patients with more severe renal insufficiency (Ccr. 0 and 8ml/min), however, the serum levels of KW-1062 after 24 hrs were still about a half of the peak levels. The fall in the serum concentration was observed during 5-hr haemodialysis in a patient with renal insufficiency.<BR>2. KW-1062 was administered to 13 patients with respiratory tract infections (10 cases) and urinary tract infections (3 cases including a patient with renal insufficiency) and found to be effective in 11, fairly effective in one and non-effective in one. No significant adverse reactions were encountered.

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