化学療法剤の投与法にかんする実験的解析

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書誌事項

タイトル別名
  • EXPERIMENTAL STUDIES ON ADMINISTRATION OF CHEMOTHERAPEUTIC AGENTS
  • カガク リョウホウザイ ノ トウヨホウ ニ カンスル ジッケンテキ カイセキ
  • VI. EFFECT OF TICARCILLIN AGAINST <I>PSEUDOMONAS AERUGINOSA</I>
  • 6. 緑膿菌に対するTicarcillinの効果

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抄録

The most effective administration of a semisynthetic penicillin, ticarcillin (TIPC), has been studied in the experimental mice infection with Pseudomonas aeruginosa.<BR>1) Pseudomonas aeruginosa damaged by TIPC or carbenicillin (CBPC), when the drug was free, immediately began to regrow in vitro.<BR>2) The therapeutic efficacy of TIPC on multiple administrations was more effective than that of CBPC.<BR>3) An important factor to decide the therapeutic efficacy of TIPC and CBPC was the total duration of the effective concentration rather than the total dosing amounts of the drug.

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