Ticarcillinのグラム陰性桿菌に対する基礎的検討

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  • LABORATORY STUDIES ON ANTIBACTERIAL ACTIVITY OF TICARCILLIN AGAINST GRAM NEGATIVE BACILLI
  • Ticarcillin ノ グラム インセイ カンキン ニ タイスル キソテキ

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Ticarcillin, a new semisynthetic penicillin, was investigated on the antibacterial activity chiefly against gram-negative bacilli as Ps. aeruginosa derived from blood, and on the combination effect with aminoglycoside antibiotics to compare carbenicillin and sulbenicillin. Results obtained were as follows.<BR>1. Ticarcillin showed stronger antibacterial activity than carbenicillin and sulbenicillin against all species of Ps. aeruginosa, Enterobacter and Serratia.<BR>2. Ticarcillin and gentamicin or dibekacin were found to be synergistically bacteriostatic against all strains of Ps. aeruginosa, the effect being 8-16 times stronger compared with a single administration. Compared with sulbenicillin, ticarcillin was shown to inhibit the growth of Ps. aeruginosa equally to sulbenicillin with 1/2 concentration of sulbenicillin, if concentration of gentamicin was fixed.

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