外科領域におけるCefotiam hexetilの臨床的検討

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  • CEFOTIAM HEXETIL IN THE SURGICAL FIELD

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We performed basic and clinical studies on cefotiam hexetil (CTM-HE), a new oral cephalosporin pro-drug of cefotiam (CTM) in the surgical field.<BR>The results are as follows:<BR>1) Antibacterial activity: MICS of CTM were determined for three clinical isolates: Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. Peak values were 1.6μg/ml, 0.2μg/ml and 0.2μg/ml, respectively. These values surpassed those of cefaclor (CCL) and amoxicillin (AMPC) against the same organisms. However, cefotiam hexetil was not shown to be better than cefixime (CFIX) against K. pneumoniae.<BR>2) Clinical results: cefotiam hexetil was used in treating 15 patients with soft tissue infections. Results were excellent in 5 cases, good in 8 and fair in 2. The efficacy rate was 86.7%. Adverse reactions were observed in only 1 case, and clinical laboratory tests revealed no abnormalities.

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