Panipenem/betamipronの実験動物における体内動態ラットおよびイヌにおけるpanipenem/betamipronの分布, 代謝および排泄
書誌事項
- タイトル別名
-
- METABOLIC STUDIES ON PANIPENEM/BETAMIPRON DISTRIBUTION, METABOLISM AND EXCRETION OF PANIPENEM/BETAMIPRON IN RATS AND DOGS
抄録
Drug metabolism and disposition studies on panipenem/betamipron (PAPM/BP) were performed by using 14C-labeled panipenem ([14C] PAPM) and betamipron ([14C]BP).<BR>Drugs were administered intravenously as [14C] PAPM/BP, PAPM/[14C] BP, [14C] PAPM or [14C] BP in rats and dogs.[14C] PAPM and [14C] BP were mainly excreted to the urine after being distributed to the kidney, liver, lung or blood. Plasma concentration, excretion rate or tissue distribution of radioactivity in rats between [14C] PAPM/BP and [14C] PAPM alone and between PAPM/[14C] BP and [14C] BP alone gave almost no differences except in the kidney distribution.<BR>In the kidney, the maximum distribution time of [14C] PAPM was delayed by combination dose with BP.
収録刊行物
-
- CHEMOTHERAPY
-
CHEMOTHERAPY 39 (Supplement3), 206-226, 1991
公益社団法人 日本化学療法学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206285032064
-
- NII論文ID
- 130004197447
-
- ISSN
- 18845894
- 00093165
-
- データソース種別
-
- JaLC
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可