The Water Retention Effects and Action for Atopic Dermatitis-like Symptoms of Ethyl Alcohol Extract (from Tamogi-take Mushroom) on Animal Model of Atopic Dermatitis

Tomiyama Takahiro, Kaihou Shinobu, Ishida Masami, Nishikawa Hidetoshi, Yamazaki Noriyuki, Tsuji Kiyomi, Mitsutake Susumu, Igarashi Yasuyuki

doi:10.4327/jsnfs.61.21

Bibliographic Information

Other Title

タモギタケエタノール抽出物のアトピー性皮膚炎モデルマウスを用いた保湿作用およびアトピー様症状に対する作用
タモギタケエタノールチュウシュツブツノアトピーセイヒフエンモデルマウスオモチイタホシツサヨウオヨビアトピーヨウショウジョウニタイスルサヨウ

Search this article

Description

Most patients with atopic dermatitis suffer from dry skin, deterioration of epidermal barrier function, and dermatitis. Hairless mice (HR-1) are a well known animal model for studies of skin abnormalities such as atopic dermatitis. Atopic dermatitis-like symptoms can be induced in these animals by feeding them a specific diet, known as the HR-AD. Using this animal model, we examined the effects of oral administration of an ethyl alcohol extract of tamogi-take, an edible mushroom that contains a high concentration of glucosyl ceramide (hereafter referred to as tamogi-take extract), on atopic dermatitis. The control group (HR-AD-fed mice) showed typical atopic dermatitis, with gradual transepidermal water loss (TEWL), keratinization and cellular infiltration into dermis. However, these conditions were ameliorated in the mice fed the tamogi-take extract (oral administration weight % of tamogi-take extract: 0.1% and 0.01% as glucosyl ceramide). Thus, in this study using hairless mice, epidermal barrier dysfunction induced by HR-AD was shown to be ameliorated by oral administration of tamogi-take extract.

Journal

Nippon Eiyo Shokuryo Gakkaishi

Nippon Eiyo Shokuryo Gakkaishi 61 (1), 21-26, 2008

Japan Society of Nutrition and Food Science

Keywords

Details 詳細情報について

Export