書誌事項
- タイトル別名
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- Biological Properties of Fucoidans Differing in Molecular Weight and Composition: Effects on Lymphocyte Proliferation and Immunological Function
- ブンシリョウ オヨビ コウセイ セイブン ノ チガイ ニ ヨル フコイダン ノ セイブツ カッセイ リンパキュウ ノ ゾウショク ト メンエキ キノウ エ ノ エイキョウ
- Effects on Lymphocyte Proliferation and Immunological Function
- リンパ球の増殖と免疫機能への影響
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説明
We examined the effects of fucoidans differing in molecular weight and composition extracted from Cladosiphon okamuranus Tokida and Fucus vesiculosus on lymphocyte-mediated immunological function and the proliferative responses of normal lymphocytes and leukemic cells. Fucoidan from Fucus vesiculosus, which contains a low proportion of uronic acid and a high proportion of sulfate, strongly inhibited the proliferative responses of normal activated lymphocytes and leukemic cells and induction of apoptosis. In contrast, fucoidan from Cladosiphon okamuranus which contains a higher proportion of uronic acid and a lower proportion of sulfate, exhibited both mitogenic activity against normal T lymphocytes and efficient production of inflammatory cytokines from macrophages at low concentrations. These fucoidans showed less inhibitory activity against leukemic cells and activated lymphocytes. Our results suggest that the biological properties of fucoidans as either immuno-stimulators or apoptosis inducers may be dependent on molecular weight, or differences in the components of polysaccharides.
収録刊行物
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- 日本栄養・食糧学会誌
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日本栄養・食糧学会誌 58 (5), 273-280, 2005
公益社団法人 日本栄養・食糧学会
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詳細情報 詳細情報について
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- CRID
- 1390001206291963392
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- NII論文ID
- 10026884322
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- NII書誌ID
- AN00311992
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- COI
- 1:CAS:528:DC%2BD2MXhtFynt7nP
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- ISSN
- 18832849
- 02873516
- http://id.crossref.org/issn/02873516
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- NDL書誌ID
- 7695587
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可