Effect of Fermented Black Garlic on Hepatic Function in Japanese Adults

Kawasaki Yuuki, Yagi-Tamura Kanako, Goto Junpei, Shimizu Kuniyoshi, Ohnuki Koichiro

doi:10.4327/jsnfs.70.109

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Other Title

黒ニンニク含有サプリメント摂取による肝機能保護作用
黒ニンニク含有サプリメント摂取による肝機能保護作用 : プラセボ対照・二重盲検・ランダム化比較試験
クロニンニクガンユウサプリメントセッシュニヨルカンキノウホゴサヨウ : プラセボタイショウ・ニジュウモウケン・ランダムカヒカクシケン
―A Placebo-controlled, Double-blinded, Randomized Trial―
―プラセボ対照・二重盲検・ランダム化比較試験―

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<p>OBJECTIVE: The objective of this study was to evaluate the effect of fermented black garlic on hepatic function in Japanese adults. TRIAL DESIGN: A placebo-controlled, double-blinded, randomized trial. METHODS: Forty subjects were randomly assigned to either a garlic group (GG) or the placebo group (PG) , and instructed to take the assigned supplements for 12 weeks. Blood tests (hepatic and renal functions, and sugar and lipid metabolism) and physical measurements were conducted before intake (baseline) , and at weeks 6 and 12. RESULTS: The change in the level of ALT, a marker of hepatic function, between the baseline and week 12 was significantly smaller in the GG than in the PG (p＝0.049) , and the change in the level of AST also tended to be smaller in the former than in the latter (p＝0.099) . CONCLUSION: Our findings suggest that intake of fermented black garlic for 12 weeks has a beneficial effect on hepatic function in healthy Japanese adults. This study has been registered in UMIN-CTR (UMIN000024771) .</p>

Journal

Nippon Eiyo Shokuryo Gakkaishi

Nippon Eiyo Shokuryo Gakkaishi 70 (3), 109-115, 2017

Japan Society of Nutrition and Food Science

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