Effect of L-Arabinose on Blood Glucose Level after Ingestion of Sucrose-containing Food in Human.
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- Inoue Shuji
- Division of Geriatric Health and Nutrition, National Institute of Health and Nutrition
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- Sanai Kazuko
- Enzymes & Pharmaceuticals Research Laboratory, Godo Shusei Co., Ltd.
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- Seri Kenji
- Enzymes & Pharmaceuticals Research Laboratory, Godo Shusei Co., Ltd.
Bibliographic Information
- Other Title
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- ヒトにおけるショ糖含有食品摂取後の血糖上昇に及ぼすＬ‐アラビノースの作用
- ヒト ニ オケル ショ トウ ガンユウ ショクヒン セッシュ ゴ ノ ケットウ ジョウショウ ニ オヨボス L アラビノース ノ サヨウ
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Abstract
L-Arabinose selectively inhibits intestinal sucrase activity in vitro and suppresses the glycemic response in a dose-dependent manner in experimental animals. In the present study, we investigated the effect of L-arabinose on the glycemic response of healthy volunteers and patients with type 2 diabetes. In the first experiment using a cross-over design, eight fasted normal volunteers were each given 50g of sucrose with and without 2g of L-arabinose. The increases of plasma glucose and serum insulin were significantly lower in the individuals given both L-arabinose and sugar. In the second experiment, the dose-dependency of L-arabinose was evaluated. Forty normal volunteers over 40 years old were given a jelly containing 30g of sucrose with added L-arabinose in ratios of 0%, 2%, 3% and 4% (w/w)(n=10). L-Arabinose at 3% and 4% significantly suppressed the increase of plasma glucose at 30min after ingestion. In the third experiment, patients with type 2 diabetes (n=10) were given the jelly with 3% (w/w) added L-arabinose using a cross-over design. L-Arabinose suppressed the maximal increase of plasma glucose after sucrose ingestion. These results demonstrate that L-arabinose attenuates sucrose-induced hyperglycemia both in normal subjects and diabetic patients, presumably through inhibition of intestinal sucrase activity.
Journal
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- Nippon Eiyo Shokuryo Gakkaishi
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Nippon Eiyo Shokuryo Gakkaishi 53 (6), 243-247, 2000
Japan Society of Nutrition and Food Science
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Keywords
Details 詳細情報について
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- CRID
- 1390001206292915072
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- NII Article ID
- 10009714805
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- NII Book ID
- AN00311992
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- COI
- 1:CAS:528:DC%2BD3MXksVGguw%3D%3D
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- ISSN
- 18832849
- 02873516
- http://id.crossref.org/issn/02873516
- http://id.crossref.org/issn/00346659
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- NDL BIB ID
- 5607234
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed