Prophylactic Effects of Sesamin on Ischemic Cerebral Injury in Stroke-Prone Spontaneously Hypertensive Rats.
- Other Title
- 脳卒中易発症性高血圧自然発症ラツトの血圧,脳血管病変および寿命に及ぼすDHA強化ユーグレナ (Euglena gracilis Z) の影響
- 脳卒中易発症性高血圧自然発症ラットの脂質代謝に及ぼすDHA強化ユーグレナ (Euglena gracilis Z) の影響
- ノウソッチュウ イハッショウセイ コウケツアツ シゼン ハッショウ ラット ノ
Search this article
As part of a basic study on the prevention of ischemic cerebral injury, sesamin (5g/kg Funabashi SP diet) was administered to stroke-prone spontaneously hypertensive rats (SHRSP) for 8 weeks from 8 weeks of age, and pathological and biochemical changes in the cerebral cortex were examined and compared with those in normotensive Wistar-Kyoto rats (WKY). In the control SHRSP, cerebral softening was found in 4 of 8 rats (50%), whereas no pathological changes were evident in sesamin-treated rats. In control SHRSP, the uric acid content of the cerebral cortex was extremely high in comparison with that in control WKY, but it was significantly lower (p<0.05) in sesamin-treated SHRSP. On the other hand, superoxide dismutase (SOD) activity was lower (p<0.05) and Na/K-ATPase was higher (p<0.05) in sesamin-treated SHRSP than in WKY. These results indicate that lipid peroxidation caused by free radicals is an important factor in ischemic cerebral injury, and that sesamin plays an important role in the scavenging of free radicals, thus preventing cerebral softening in SHRSP.
- Nippon Eiyo Shokuryo Gakkaishi
Nippon Eiyo Shokuryo Gakkaishi 48 (3), 189-193, 1995
Japan Society of Nutrition and Food Science