Prophylactic Effects of Sesamin on Ischemic Cerebral Injury in Stroke-Prone Spontaneously Hypertensive Rats.

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  • MURAKAMI Tetsuo
    Department of Food Science and Nutrition, Faculty of Agriculture, Kinki University
  • YOSHIZUMI Hajime
    Department of Food Science and Nutrition, Faculty of Agriculture, Kinki University
  • ITO Hiroyuki
    Research Institute of Hypertension, Kinki University

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  • 脳卒中易発症性高血圧自然発症ラットの虚血性脳障害に対するセサミンの予防効果
  • ノウソッチュウ イハッショウセイ コウケツアツ シゼン ハッショウ ラット ノ

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Abstract

As part of a basic study on the prevention of ischemic cerebral injury, sesamin (5g/kg Funabashi SP diet) was administered to stroke-prone spontaneously hypertensive rats (SHRSP) for 8 weeks from 8 weeks of age, and pathological and biochemical changes in the cerebral cortex were examined and compared with those in normotensive Wistar-Kyoto rats (WKY). In the control SHRSP, cerebral softening was found in 4 of 8 rats (50%), whereas no pathological changes were evident in sesamin-treated rats. In control SHRSP, the uric acid content of the cerebral cortex was extremely high in comparison with that in control WKY, but it was significantly lower (p<0.05) in sesamin-treated SHRSP. On the other hand, superoxide dismutase (SOD) activity was lower (p<0.05) and Na/K-ATPase was higher (p<0.05) in sesamin-treated SHRSP than in WKY. These results indicate that lipid peroxidation caused by free radicals is an important factor in ischemic cerebral injury, and that sesamin plays an important role in the scavenging of free radicals, thus preventing cerebral softening in SHRSP.

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