熱処理により調製したラクトオリゴ糖の生理効果

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  • Physiological Effects of Lactooligosaccharide Obtained by Heat Treatment of Lactose.
  • ネツ ショリ ニ ヨリ チョウセイシタ ラクト オリゴトウ ノ セイリ コウカ

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Recently we developed a lactooligosaccharide (PL) with an average molecular weight of 750 obtained by heat treatment of lactose. In the present study we examined the effects of PL on physiological functions such as bowel movement, blood glucose, and serum cholesterol. The results are summarized as follows: 1) PL was resistant to salivary amylase, pancreatic amylase, and intestinal mucosa disaccharidase in vitro. 2) PL was well fermented in vitro by some strains of Bifidobacterium and Bacteroides but not by many strains of Clostridium and E. coli. 3) The excretion ratio in feces after a single administration of PL was estimated to be 36% in rats. 4) In rats fed a basal diet supplemented with 5% PL, gastrointestinal transit time was significantly shorter (7.7±0.9h) than that of control rats (12.1±0.5h). 5) The percentage area under the curve of plasma glucose after PL loading at 1.5g/kg body weight was 35%, compared with lactose loading at 1.5g/kg body weight. 6) The level of serum total cholesterol in rats fed a cholesterol-free high-sucrose diet for 4 weeks was signifi cantly higher than in rats fed a 10% PL-supplemented diet. 7) No significant changes were shown in serum GPT, BUN, total protein, and haemogram in rats fed a 5-10% PL-supplemented diet for 4 weeks.

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