Modulation of Core Body Temperature by Amino Acids (Young Investigator Award of JSNFS (2010))

DOI JASI Web Site 40 References
  • Yamaoka Ippei
    Research and Development Center, Otsuka Pharmaceutical Factory, Inc.

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  • アミノ酸による体温とエネルギー代謝制御に関する研究　　（平成２２年度日本栄養・食糧学会奨励賞受賞）
  • アミノサン ニ ヨル タイオン ト エネルギー タイシャ セイギョ ニ カンスル ケンキュウ ヘイセイ 22ネンド ニホン エイヨウ ショクリョウ ガッカイ ショウレイショウ ジュショウ
  • Modulation of Core Body Temperature by Amino Acids
  • (Young Investigator Award of JSNFS (2010))
  • (平成22年度日本栄養・食糧学会奨励賞受賞)

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Anesthetics impair core body temperature (Tcore) homeostasis, resulting in a reduction of Tcore during surgery that is associated with a poorer postoperative outcome. We attempted to prevent such a decrease of Tcore in rats by infusion of a solution of amino acids (AAs) during anesthesia. The infusion enhanced muscle protein synthesis accompanied by obvious increases in plasma insulin and translation initiation activities in comparison with the conscious state. The increased plasma insulin contributed to the linkage acceleration of muscle protein synthesis, themogenesis and heat storage by AAs. The AAs also enhanced myofibrillar protein breakdown. These findings provide supportive evidence for the connection that enhancement of protein turnover by AAs contributes to Tcore modification. Branched chain amino acids play an important role in heat accumulation, and isoleucine then contributes to control of glucose and energy metabolism. We also demonstrated that dietary protein modulates circadian Tcore fluctuation differently in rats during the dark and light phases. These findings suggest that AAs contribute considerably to Tcore modification, which is an important vital sign.

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